Apoptotic induction and antimigratory effects of rhazya. Rhazya stricta is a unique medicinal plant source for many indole alkaloids, nonalkaloids, flavonoids, triterpenes and other unknown molecules with. Similar results were reported by alfarraj and alwabel 2009. Seed oil from harmal rhazya stricta decne grown in riyadh saudi arabia. Seed oil from harmal rhazya stricta decne grown in. Efficacy of rhazya stricta leaf and seed extracts against rhyzopertha dominica and trogoderma granarium. Obaid 1, sreedhara voleti 2, roop singh bora3,4, nahid h. The aqueous rhazya stricta decne leaves extract was found to be a highly efficient inhibitor for mild steel in 1. Antibacterial activities of rhazya stricta leaf extracts. In vitro antifungal activity of rhazya stricta article pdf available in pakistan journal of pharmaceutical sciences 204. Taxonomy of rhazya stricta decne family apocynaceae in saudi arabia is well documented. Ibhrahim department of botany and microbiology, college of science, king saud university, po box22452, riyadh 11495, saudi arabia. Climate change is predicted to be a serious threat to agriculture due to the need for crops to be able to tolerate increased heat stress. Request pdf on jan 1, 2007, gilani sa and others published monograph on rhazya stricta find, read and cite all the research you need on researchgate.
Rhazinilam 1 was first isolated in 1970 by chatterjee et al. Synthesis, characterization and antibacterial activity of. Rhazya stricta decne is an important medicinal species used in indigenous medicinal herbal drugs to cure various diseases in south asia pakistan, india and afghanistan and in the middle east e. It is native to egypt and to southwestern asia from yemen to india species. Antioxidant properties of methanolic extracts from leaves. The role of alkaloids isolated from rhazya stricta decne. Pdf seed oil from harmal rhazya stricta decne grown in.
The nuclear genome of rhazya stricta and the evolution of alkaloid. Rhazya is unique among the eight sequenced asterids in the types of events that have shaped the evolution of its mitochondrial genome. The methanolic extract exhibited the highest total phenolic content among the extracts. Yemen, saudi arabia, oman, persian gulf sheikdoms, iraq, iran, afghanistan, pakistan, india, western himalayas. Text is available under the creative commons attributionsharealike license. Phytochemical, pharmacological and toxicological properties of the medicinal plant rhazya stricta decne. Download fulltext pdf download fulltext pdf download fulltext pdf. Phytochemical, pharmacological and ethnobotanical studies. Effects of crude extracts from medicinal herbs rhazya. Establishment of transgenic rhazya stricta hairy roots to modulate terpenoid indole alkaloid production. Pdf rhazya stricta decne is an important medicinal species used in. Rhazya is a genus of plant in family apocynaceae first described as a genus in 1835.
Pdf phytochemical and taxonomic evaluation of rhazya stricta in. Therefore, in the present work we aimed at testing, in this species, the possible protective effect of r. Analysis of transcriptional response to heat stress in. It is widely distributed throughout western asia from yemen to arabia throughout the middle east, to the north west province of india, south asia and abundantly found in various regions of pakistan gilani et al. Effect of rhazya stricta decne on monoamine oxidase and. This study was focused on biotechnological production tools of r. The cytotoxic effects of these fractions on human breast cancer cells mdamb231 and mcf7 and nontumorigenic control cells mcf10a were. Rhazya stricta is a medicinal plant that is widely used in saudi folklore medicine for treatment of various diseases. The prepared activated carbon was characterized by ftir and sem analysis. It contains a large number of terpenoid indole alkaloids tias, some of which possess interesting pharmacological properties. Cheminformatics studies to analyze the therapeutic.
Mountain, plain and wadi diversity on growth behavior and metabolic activities of one common perennial dwarf shrub rhazya stricta. Some of its alkaloids have been reported to have anticancerous properties. Immobility time s in the forced swimming test measured in control rats and in rats treated with rhazya stricta extract 6. However, in most cases the biological activity of these compounds has not been studied. The effect of treatment with the medicinal plant rhazya.
Several types of alkaloids and a few flavonoids have been isolated and their structures and stereochemistry characterized. Rhazya stricta is an evergreen shrub that is native to extremely hot regions across western and south asia. Naturally occurring cyclotryptophans and cyclotryptamines. By comparing tf values, it could be compare the ability of different plant species in taking up heavy metals from the contaminated soil and translocations them in the plant canopy. It produces a large number of terpenoid indole alkaloids tias some of which possess important pharmacological properties.
Synthesis, characterization and antibacterial activity of silver nanoparticles using rhazya stricta. Pdf in vitro antifungal activity of rhazya stricta researchgate. A novel activated carbon was prepared from rhazya stricta leaves and was successfully used as an adsorbent for phenol removal from aqueous solution. The study material including transgenic hairy root cultures have been developed and their potential for alkaloid production are being investigated. The effect of treatment with the medicinal plant rhazya stricta decne, on monoamine oxidase mao and cholinesterase activity, and on the concentration of brain biogenic amines was studied in rats. Adsorption of phenol onto activated carbon from rhazya. Several metals such as silver, gold, iron, titanium, zinc, magnesium and copper have been subjected to nanoformulation for a wide range of useful applications. Review history for synthesis, characterization and. Saifine and nmethylleuconolam, new indole alkaloids from rhazya stricta. Semantic scholar extracted view of scientific name. The present study was planned to investigate the antitumor efficacy of teucrium oliverianum and rhazya stricta in chemicallyinduced hepatocellular carcinoma hcc in rats. However, the yields of these compounds are very low. Sabir3 and kulvinder singh saini3,4 abstract rhazya stricta is a unique medicinal plant source for many indole alkaloids, nonalkaloids, flavonoids, triterpenes and. Original article phytochemical and taxonomic evaluation of rhazya stricta in saudi arabia najat a.
Transcriptomic analysis of salt stress responsive genes in. It is used as a medicinal plant in traditional cultures and the seeds are a source of unsaturated oil. Rhazya stricta is an evergreen shrub that is widely distributed across western and south asia, and like many other members of the apocynaceae produces monoterpene indole alkaloids that have anticancer properties. Uae rhazya stricta decne extract as a corrosion inhibitor. Apocynaceae is an important medicinal plant that is widely distributed in the middle east and indian subcontinent. This name is the accepted name of a species in the genus rhazya family apocynaceae the record derives from wcsp data supplied on 20120323 which reports it as an accepted name record 177985 with original publication details. Phytochemical and taxonomic evaluation of rhazya stricta. Rhazya stricta is a medicinally important plant native to south asia. Determination of terpenoid indole alkaloids in hairy roots. The rhazya stricta exhibiting tf values less than one except for zn 1. Three factors namely, temperature, ph and adsorbent dose were screened to study their effect on the adsorption of phenol by r.
Establishment of a reliable, reproducible and efficient transformation. Antibacterial activities of rhazya stricta leaf extracts against multidrugresistant human pathogens raziuddin khan a, mohammed n. In the uplcms analyses, a total of 20 tias were identified from crude extracts. In addition to generating genomic resources for this medicinally important plant, analyses of the complete plastid and mitochondrial genomes and a nuclear transcriptome from rhazya provide insights into intercompartmental. Biotechnology of the medicinal plant rhazya stricta. Rhazya stricta decne is an important medicinal species used in indigenous medicinal herbal drugs to cure. Rhazya stricta decne harmal, a member of the apocynaceae family, is an important medicinal species used in folkloric medicine to cure various diseases in south asia and the middle east 11, 12. Rhazya stricta diceisne, a gregarious dwarf shrub which grows wild in west pakistan and is rich in alkaloids14, proved to have a leucopenic effect. Apocynaceae is a traditional medicinal plant in middle east and south asia. Apocynaceae is a medicinal plant rich in terpenoid indole alkaloids tias, some of which possess important pharmacological properties. Phytochemical and taxonomic evaluation of rhazya stricta in saudi.
In the present study, tocol tocopherol and tocotrienol, triacylglycerol, and fatty acid compositions, pigment content, thermal behavior, and various physicochemical properties of. The aim of our study is to examine the morphological and. Eshvarak is a native poisonous plant in southern iran, afghanistan, pakistan, india, iraq, oman, yemen, and saudi arabia. Rhazyaminine from rhazya stricta inhibits metastasis and induces. Teucrium oliverianum and rhazya stricta are medicinal plants used in traditional and herbal medicine for the treatment of diabetes, liver diseases and inflammatory conditions. The present study was conducted to evaluate the allelopathic potential of two invasive plants namely rhazya stricta and artemisia monosperma on the growth of zea mays agricultural plant and lasiurus scindicus range plant inoculated with. Analysis of indole alkaloids from rhazya stricta hairy. The role of alkaloids isolated from rhazya stricta decne apocynaceae family rs in targeting genes involved in cancer and metastasis remains to be elucidated. Generation of oxygen free radicals in kidney cortex plays an important role in the pathogenesis of gentamicin gm nephrotoxicity, and the leaf extract of the medicinal plant rhazya stricta has been shown to have an antioxidant action in rats. Structure and absolute configuration of strictamine and. Saudi arabia, qatar, united arab emirates uae, iran and iraq. Background green synthesis of metallic nanoparticles has gained significant attention in the field of nanomedicine as an environmentfriendly and costeffective alternative in comparison with other physical and chemical methods. Phytochemistry, pharmacology and toxicity of rhazya. Rhazya stricta decaisne apocynaceae is characterized by its high contents of certain indole alkaloids chatterjee et al.
Rhazya stricta wikispecies wikispecies, free species. This study focused on the composition of alkaloids obtained from transformed hairy root cultures of r. Pdf allelopathic impact of rhazya stricta dence and. Chemical investigations of roots and leaves of rhazya stricta have resulted in the isolation of the new indole alkaloids, 16r19,20eisositsirikine acetate. Growth and metabolic responses of rhazya stricta decne to habitat. Rhazya stricta is native to arid regions in south asia and the middle east and is used extensively in folk medicine to treat a wide range of diseases. Identify and characterize new compounds from rs, which inhibit genes involved in the survival, invasion, selfrenewal, and metastatic processes of cancer cells. Pdf the indolealkaloid fraction of rhazya stricta improves key. This species is adapted to very harsh desert conditions making it an excellent system for studying tolerance to high temperatures and salinity.